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Effects of mutation, truncation and temperature on the folding kinetics of a WW domain

The purpose of this work is to show how mutation, truncation and change of temperature can influence the folding kinetics of a protein. This is accomplished by principal component analysis (PCA) of molecular dynamics (MD)-generated folding trajectories of the triple β-strand WW domain from the Formi...

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Detalles Bibliográficos
Main Authors: Maisuradze, Gia G., Zhou, Rui, Liwo, Adam, Xiao, Yi, Scheraga, Harold A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586707/
https://ncbi.nlm.nih.gov/pubmed/22560992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.04.027
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