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In vitro mutagenesis of Caenorhabditis elegans cuticle collagens identifies a potential subtilisin-like protease cleavage site and demonstrates that carboxyl domain disulfide bonding is required for normal function but not assembly.

The importance of conserved amino acids in the amino and carboxyl non-Gly-X-Y domains of Caenorhabditis elegans cuticle collagens was examined by analyzing site-directed mutations of the sqt-1 and rol-6 collagen genes in transgenic animals. Altered collagen genes on transgenic arrays were shown to p...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Principais autores: Yang, J, Kramer, J M
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358638/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8139571/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.4.2722-2730.1994
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