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Ovarian Cancer Cells, not Normal Cells, Are Damaged by Mirk/Dyrk1B Kinase Inhibition
Prior studies had shown that the Mirk/dyrk1B gene is amplified/upregulated in about 75% of ovarian cancers, that protein levels of this kinase are elevated in quiescent G0 cells, and that Mirk maintains tumor cells in quiescence by initiating rapid degradation of cyclin D isoforms and by phosphoryla...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586305/ https://ncbi.nlm.nih.gov/pubmed/23114871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27917 |
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