Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.

The tyrosine protein kinase p56lck transduces signals important for antigen-induced T-cell activation. In transgenic mice, p56lck is oncogenic when overexpressed or expressed as a mutant, catalytically activated enzyme. In humans, the LCK gene is located at the breakpoint of the t(1;7)(p34;q34) chro...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Wright, D D, Sefton, B M, Kamps, M P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8139546/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.4.2429-2437.1994
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