Safety, Tolerability, and Pharmacokinetics of Etamicastat, a Novel Dopamine-β-Hydroxylase Inhibitor, in a Rising Multiple-Dose Study in Young Healthy Subjects

Background: Activation of the sympathetic nervous system is an important feature in hypertension and congestive heart failure. A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-β-hydroxylase (DβH)....

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Autores principales: Nunes, Teresa, Rocha, José F., Vaz-da-Silva, Manuel, Igreja, Bruno, Wright, Lyndon C., Falcão, Amílcar, Almeida, Luis, Soares-da-Silva, Patricio
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2012
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Original Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585840/
https://ncbi.nlm.nih.gov/pubmed/21171669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2165/11586310-000000000-00000
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