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Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila
Atg6 (beclin 1 in mammals) is a core component of the Vps34 complex that is required for autophagy. Beclin 1 (Becn1) functions as a tumor suppressor, and Becn1(+/-) tumors in mice possess elevated cell stress and p62 levels, altered NF-κB signaling and genome instability. The tumor suppressor functi...
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Main Authors: | , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Company of Biologists
2013
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585664/ https://ncbi.nlm.nih.gov/pubmed/23406899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.089490 |
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