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Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila

Atg6 (beclin 1 in mammals) is a core component of the Vps34 complex that is required for autophagy. Beclin 1 (Becn1) functions as a tumor suppressor, and Becn1(+/-) tumors in mice possess elevated cell stress and p62 levels, altered NF-κB signaling and genome instability. The tumor suppressor functi...

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Bibliografiske detaljer
Main Authors: Shravage, Bhupendra V., Hill, Jahda H., Powers, Christine M., Wu, Louisa, Baehrecke, Eric H.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585664/
https://ncbi.nlm.nih.gov/pubmed/23406899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.089490
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