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Clinical and Biological Relevance of Genomic Heterogeneity in Chronic Lymphocytic Leukemia

BACKGROUND: Chronic lymphocytic leukemia (CLL) is typically regarded as an indolent B-cell malignancy. However, there is wide variability with regards to need for therapy, time to progressive disease, and treatment response. This clinical variability is due, in part, to biological heterogeneity betw...

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Bibliographic Details
Main Authors: Friedman, Daphne R., Lucas, Joseph E., Weinberg, J. Brice
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585365/
https://ncbi.nlm.nih.gov/pubmed/23468975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057356
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