The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells

While Mesd was discovered as a specialized molecular endoplasmic reticulum chaperone for the Wnt co-receptors LRP5 and LRP6, recombinant Mesd protein is able to bind to mature LRP5 and LRP6 on the cell surface and acts as a universal antagonist of LRP5/6 modulators. In our previous study, we found t...

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Autori principali: Lin, Cuihong, Lu, Wenyan, Zhang, Wei, Londoño-Joshi, Angelina I., Buchsbaum, Donald J., Bu, Guojun, Li, Yonghe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585277/
https://ncbi.nlm.nih.gov/pubmed/23469146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058102
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