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Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host

The overexpression of activated, myristoylated Akt in the midgut of female transgenic Anopheles stephensi results in resistance to infection with the human malaria parasite Plasmodium falciparum but also decreased lifespan. In the present study, the understanding of mitochondria-dependent midgut hom...

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書誌詳細
主要な著者: Luckhart, Shirley, Giulivi, Cecilia, Drexler, Anna L., Antonova-Koch, Yevgeniya, Sakaguchi, Danielle, Napoli, Eleonora, Wong, Sarah, Price, Mark S., Eigenheer, Richard, Phinney, Brett S., Pakpour, Nazzy, Pietri, Jose E., Cheung, Kong, Georgis, Martha, Riehle, Michael
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585164/
https://ncbi.nlm.nih.gov/pubmed/23468624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003180
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