Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host

The overexpression of activated, myristoylated Akt in the midgut of female transgenic Anopheles stephensi results in resistance to infection with the human malaria parasite Plasmodium falciparum but also decreased lifespan. In the present study, the understanding of mitochondria-dependent midgut hom...

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Autori principali: Luckhart, Shirley, Giulivi, Cecilia, Drexler, Anna L., Antonova-Koch, Yevgeniya, Sakaguchi, Danielle, Napoli, Eleonora, Wong, Sarah, Price, Mark S., Eigenheer, Richard, Phinney, Brett S., Pakpour, Nazzy, Pietri, Jose E., Cheung, Kong, Georgis, Martha, Riehle, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585164/
https://ncbi.nlm.nih.gov/pubmed/23468624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003180
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