MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice

Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life with Huntington's disease or myotonic dystrophy. Broad ranges of repeat instability arise between individuals with expanded repeats,...

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Autores principales: Tomé, Stéphanie, Manley, Kevin, Simard, Jodie P., Clark, Greg W., Slean, Meghan M., Swami, Meera, Shelbourne, Peggy F., Tillier, Elisabeth R. M., Monckton, Darren G., Messer, Anne, Pearson, Christopher E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585117/
https://ncbi.nlm.nih.gov/pubmed/23468640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003280
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