The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit: IMPLICATIONS FOR IMPROVED IL-12 CYTOKINE PRODUCTION

IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 biosynthesis at the posttranscriptional and posttranslational levels were investigated. We show that the combination of RNA/codon-opti...

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Autores principales: Jalah, Rashmi, Rosati, Margherita, Ganneru, Brunda, Pilkington, Guy R., Valentin, Antonio, Kulkarni, Viraj, Bergamaschi, Cristina, Chowdhury, Bhabadeb, Zhang, Gen-Mu, Beach, Rachel Kelly, Alicea, Candido, Broderick, Kate E., Sardesai, Niranjan Y., Pavlakis, George N., Felber, Barbara K.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585113/
https://ncbi.nlm.nih.gov/pubmed/23297419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436675
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