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Scanning the Topography of Polyamine Blocker Binding in an Inwardly Rectifying Potassium Channel
Steeply voltage-dependent inward rectification of Kir (inwardly rectifying potassium) channels arises from blockade by cytoplasmic polyamines. These polycationic blockers traverse a long (>70 Å) pore, displacing multiple permeant ions, en route to a high affinity binding site that remains loosely...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3585099/ https://ncbi.nlm.nih.gov/pubmed/23300089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383794 |
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