Scanning the Topography of Polyamine Blocker Binding in an Inwardly Rectifying Potassium Channel

Steeply voltage-dependent inward rectification of Kir (inwardly rectifying potassium) channels arises from blockade by cytoplasmic polyamines. These polycationic blockers traverse a long (>70 Å) pore, displacing multiple permeant ions, en route to a high affinity binding site that remains loosely...

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Main Authors: Kurata, Harley T., Akrouh, Alejandro, Li, Jenny B. W., Marton, Laurence J., Nichols, Colin G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585099/
https://ncbi.nlm.nih.gov/pubmed/23300089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.383794
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