Structural Basis for a Bispecific NADP(+) and CoA Binding Site in an Archaeal Malonyl-Coenzyme A Reductase

Autotrophic members of the Sulfolobales (crenarchaeota) use the 3-hydroxypropionate/4-hydroxybutyrate cycle to assimilate CO(2) into cell material. The product of the initial acetyl-CoA carboxylation with CO(2), malonyl-CoA, is further reduced to malonic semialdehyde by an NADPH-dependent malonyl-Co...

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Detalhes bibliográficos
Main Authors: Demmer, Ulrike, Warkentin, Eberhard, Srivastava, Ankita, Kockelkorn, Daniel, Pötter, Markus, Marx, Achim, Fuchs, Georg, Ermler, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585071/
https://ncbi.nlm.nih.gov/pubmed/23325803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421263
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