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Reprogramming of the MicroRNA Transcriptome Mediates Resistance to Rapamycin

The mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation that is often deregulated in cancer. Inhibitors of mTOR, including rapamycin and its analogues, are being evaluated as antitumor agents. For their promise to be fulfilled, it is of paramount importance to identify...

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Autores principales: Totary-Jain, Hana, Sanoudou, Despina, Ben-Dov, Iddo Z., Dautriche, Cula N., Guarnieri, Paolo, Marx, Steven O., Tuschl, Thomas, Marks, Andrew R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585042/
https://ncbi.nlm.nih.gov/pubmed/23300087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.416446
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