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Quantitative Analysis of Histone Modifications: Formaldehyde Is a Source of Pathological N(6)-Formyllysine That Is Refractory to Histone Deacetylases

Aberrant protein modifications play an important role in the pathophysiology of many human diseases, in terms of both dysfunction of physiological modifications and the formation of pathological modifications by reaction of proteins with endogenous electrophiles. Recent studies have identified a che...

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Detalhes bibliográficos
Main Authors: Edrissi, Bahar, Taghizadeh, Koli, Dedon, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585032/
https://ncbi.nlm.nih.gov/pubmed/23468656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003328
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