Tolerance to Effects of High-Dose Oral Δ9-Tetrahydrocannabinol and Plasma Cannabinoid Concentrations in Male Daily Cannabis Smokers

Oral cannabinoids are taken for medicinal or recreational purposes, yet little is known about tolerance to their effects after high-dose extended exposure. The development of tolerance to effects of around-the-clock oral synthetic Δ9-tetrahydrocannabinol (THC) (20 mg every 3.5–6 h) was evaluated in...

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Autori principali: Gorelick, David A., Goodwin, Robert S., Schwilke, Eugene, Schwope, David M., Darwin, William D., Kelly, Deanna L., McMahon, Robert P., Liu, Fang, Ortemann-Renon, Catherine, Bonnet, Denis, Huestis, Marilyn A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584989/
https://ncbi.nlm.nih.gov/pubmed/23074216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jat/bks081
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