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Mycobacterial Trehalose Dimycolate Reprograms Macrophage Global Gene Expression and Activates Matrix Metalloproteinases

Trehalose 6,6′-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role of TDM in the innate immune response to Mycobacterium tuberculosis, microarray analysis was used to examine gene regulation in murine bone marrow-derived macrophage...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sakamoto, Kaori, Kim, Mi Jeong, Rhoades, Elizabeth R., Allavena, Rachel E., Ehrt, Sabine, Wainwright, Helen C., Russell, David G., Rohde, Kyle H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584883/
https://ncbi.nlm.nih.gov/pubmed/23264051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00906-12
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