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Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.

Src family protein tyrosine kinases (PTKs) play an essential role in antigen receptor-initiated lymphocyte activation. Their activity is largely regulated by a negative regulatory tyrosine which is a substrate for the activating action of the CD45 phosphotyrosine phosphatase (PTPase) or, conversely,...

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Detalhes bibliográficos
Main Authors: Autero, M, Saharinen, J, Pessa-Morikawa, T, Soula-Rothhut, M, Oetken, C, Gassmann, M, Bergman, M, Alitalo, K, Burn, P, Gahmberg, C G
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC358486/
https://ncbi.nlm.nih.gov/pubmed/7507203
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