Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells

The specific 26S proteasome inhibitor, bortezomib (BZ) potently induces apoptosis as well as autophagy in metastatic breast cancer cell lines such as MDA-MB-231 and MDA-MB-468. The combined treatment of clarithromycin (CAM) and BZ significantly enhances cytotoxicity in these cell lines. Although tre...

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Hauptverfasser: KOMATSU, SEIICHIRO, MIYAZAWA, KEISUKE, MORIYA, SHOTA, TAKASE, AKIKO, NAITO, MUNEKAZU, INAZU, MASATO, KOHNO, NORIO, ITOH, MASAHIRO, TOMODA, AKIO
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584821/
https://ncbi.nlm.nih.gov/pubmed/22200786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1317
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