Concurrent Assessment of Hepatic and Intestinal Cytochrome P450 3A Activities Using Deuterated Alfentanil

Alfentanil is a validated probe for hepatic, first-pass, and intestinal cytochrome P450 (CYP) 3A activity, using plasma clearances, single-point concentrations and noninvasive pupil diameter change (miosis). Assessing intravenous and oral drug disposition typically requires separate dosing. This inv...

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Hlavní autoři: Kharasch, Evan D., Vangveravong, Suwanna, Buck, Nikki, London, Amy, Kim, Thomas, Blood, Jane, Mach, Robert H
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584707/
https://ncbi.nlm.nih.gov/pubmed/21346758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.313
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