Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.

The Ras(17N) dominant negative antagonizes endogenous Ras function by forming stable, inactive complexes with Ras guanine nucleotide exchange factors (GEFs; e.g., SOS1). We have used the growth-inhibitory phenotype of Ras(17N) to characterize two aspects of Ras interaction with GEFs. First, we used...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Quilliam, L A, Kato, K, Rabun, K M, Hisaka, M M, Huff, S Y, Campbell-Burk, S, Der, C J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358467/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8289792/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.2.1113
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