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‘Function-first’ Lead Discovery: Mode of Action Profiling of Natural Product Libraries Using Image-Based Screening
Cytological profiling is a high-content image-based screening technology that provides insight into the mode of action (MOA) for test compounds by directly measuring hundreds of phenotypic cellular features. We have extended this recently reported technology to the mechanistic characterization of un...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3584419/ https://ncbi.nlm.nih.gov/pubmed/23438757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.12.007 |
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