Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

BACKGROUND: Long-term and unresolved airway inflammation and airway remodeling, characteristic features of chronic asthma, if not treated could lead to permanent structural changes in the airways. Aldose reductase (AR), an aldo-sugar and lipid aldehyde metabolizing enzyme, mediates allergen-induced...

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Detalhes bibliográficos
Main Authors: Yadav, Umesh C. S., Naura, Amarjit S., Aguilera-Aguirre, Leopoldo, Boldogh, Istvan, Boulares, Hamid A., Calhoun, William J., Ramana, Kota V., Srivastava, Satish K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584054/
https://ncbi.nlm.nih.gov/pubmed/23460857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057442
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