Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

Recombinant adeno-associated viral (rAAV) vectors are potentially powerful tools for gene therapy of CNS diseases, but their penetration into brain parenchyma is severely limited by the blood-brain barrier (BBB) and current delivery relies on invasive stereotactic injection. Here we evaluate the loc...

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Detalhes bibliográficos
Main Authors: Hsu, Po-Hung, Wei, Kuo-Chen, Huang, Chiung-Yin, Wen, Chih-Jen, Yen, Tzu-Chen, Liu, Chao-Lin, Lin, Ya-Tin, Chen, Jin-Chung, Shen, Chia-Rui, Liu, Hao-Li
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584045/
https://ncbi.nlm.nih.gov/pubmed/23460893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057682
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