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Dissecting Protein Function: An Efficient Protocol for Identifying Separation-of-Function Mutations That Encode Structurally Stable Proteins

Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate bet...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Lubin, Johnathan W., Rao, Timsi, Mandell, Edward K., Wuttke, Deborah S., Lundblad, Victoria
التنسيق: Artigo
اللغة:Inglês
منشور في: Genetics Society of America 2013
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583993/
https://ncbi.nlm.nih.gov/pubmed/23307900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.147801
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