Human MHC Class I-restricted high avidity CD4(+) T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

In this study, we generated human MHC Class I-restricted CD4(+) T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma, nasopharyngeal carcinoma and medulloblastoma, respectively. Retroviral transfer of virus-specific, HLA-A2-restricted TC...

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Detalhes bibliográficos
Main Authors: Xue, Shao-An, Gao, Liquan, Ahmadi, Maryam, Ghorashian, Sara, Barros, Rafael D, Pospori, Constandina, Holler, Angelika, Wright, Graham, Thomas, Sharyn, Topp, Max, Morris, Emma C, Stauss, Hans J.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583927/
https://ncbi.nlm.nih.gov/pubmed/23483821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.22590
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