The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding

The β subunits of voltage-gated sodium (Na(v)) channels possess an extracellular immunoglobulin (Ig) domain that is related to the L1 family of cell-adhesion molecules (CAMs). Here we show that in HEK293 cells, secretion of the free Ig domain of the β3 subunit is reduced significantly when it is coe...

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Detalhes bibliográficos
Main Authors: Yereddi, Nikitha R., Cusdin, Fiona S., Namadurai, Sivakumar, Packman, Len C., Monie, Tom P., Slavny, Peter, Clare, Jeffrey J., Powell, Andrew J., Jackson, Antony P.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583845/
https://ncbi.nlm.nih.gov/pubmed/23118027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-209445
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