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Is intracellular pH a clock for mitosis?

Experiments have shown that the intracellular pH of many cells rises to a maximum at the onset of mitosis, subsequently decreasing 0.3 to 0.5 pH units by the end of mitosis. This result, and observations that tubulin net charge depends strongly on pH, may be critical for microtubule (MT) dynamics du...

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Detalhes bibliográficos
Main Authors: Gagliardi, L John, Shain, Daniel H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583677/
https://ncbi.nlm.nih.gov/pubmed/23402214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-10-8
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