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MG132, a proteasome inhibitor, induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion

MG132 as a proteasome inhibitor can induce apoptotic cell death in lung cancer cells. However, little is known about the toxicological cellular effects of MG132 on normal primary lung cells. Here, we investigated the effects of N-acetyl cysteine (NAC) and vitamin C (well known antioxidants) or L-but...

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Hlavní autoři: PARK, WOO HYUN, KIM, SUHN HEE
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583605/
https://ncbi.nlm.nih.gov/pubmed/22266922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2012.1642
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