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Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents

[Image: see text] Niclosamide has been identified to potently inhibit the activation, nuclear translocation, and transactivation of STAT3. Nevertheless, the poor aqueous solubility and bioavailability of niclosamide have hindered its further clinical development for cancer therapy. To discover new m...

詳細記述

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書誌詳細
主要な著者: Chen, Haijun, Yang, Zhengduo, Ding, Chunyong, Chu, Lili, Zhang, Yusong, Terry, Kristin, Liu, Huiling, Shen, Qiang, Zhou, Jia
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2013
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583367/
https://ncbi.nlm.nih.gov/pubmed/23459613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3003082
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