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Optimising the combination of thermostabilising mutations in the neurotensin receptor for structure determination
Conformational thermostabilization of G protein-coupled receptors is a successful approach for their structure determination. We have recently determined the structure of a thermostabilized neurotensin receptor NTS1 in complex with its peptide agonist and here we describe the strategy for the identi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582860/ https://ncbi.nlm.nih.gov/pubmed/23337476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2013.01.008 |
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