New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

BACKGROUND: Thromboxane A(2) is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing the incidence of complications following a...

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Detalhes bibliográficos
Main Authors: Hirz, Taghreed, Khalaf, Ali, El-Hachem, Nehme, Mrad, May F, Abdallah, Hassan, Créminon, Christophe, Grée, René, Merhi, Raghida Abou, Habib, Aïda, Hachem, Ali, Hamade, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582601/
https://ncbi.nlm.nih.gov/pubmed/23228056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-153X-6-152
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