TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

Collapse of membrane lipid asymmetry is a hallmark of blood coagulation. TMEM16F of the TMEM16 family that includes TMEM16A/B Ca(2+)-activated Cl(−) channels (CaCCs) is linked to Scott syndrome with deficient Ca(2+)-dependent lipid scrambling. We generated TMEM16F knockout mice that exhibit bleeding...

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Autores principales: Yang, Huanghe, Kim, Andrew, David, Tovo, Palmer, Daniel, Jin, Taihao, Tien, Jason, Huang, Fen, Cheng, Tong, Coughlin, Shaun R., Jan, Yuh Nung, Jan, Lily Yeh
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582364/
https://ncbi.nlm.nih.gov/pubmed/23021219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.036
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