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Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease
NPGPx is a member of the glutathione peroxidase (GPx) family; however, it lacks GPx enzymatic activity due to the absence of a critical selenocysteine residue, rendering its function an enigma. We report that NPGPx is a novel stress sensor that transmits oxidative stress signals by transferring the...
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| Главные авторы: | , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582359/ https://ncbi.nlm.nih.gov/pubmed/23123197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.007 |
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