Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease

NPGPx is a member of the glutathione peroxidase (GPx) family; however, it lacks GPx enzymatic activity due to the absence of a critical selenocysteine residue, rendering its function an enigma. We report that NPGPx is a novel stress sensor that transmits oxidative stress signals by transferring the...

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Detalhes bibliográficos
Main Authors: Wei, Pei-Chi, Hsieh, Yi-Hsuan, Su, Mei-I, Jiang, X-J, Hsu, Pang-Hung, Lo, Wen-Ting, Jeng, Yung-Ming, Wang, Ju-Ming, Chen, Phang-lang, Chang, Yi-Cheng, Lee, Kuo-Fen, Tsai, Ming-Daw, Shew, Jin-Yuh, Lee, Wen-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582359/
https://ncbi.nlm.nih.gov/pubmed/23123197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.007
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