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Predicting Efflux Ratios and Blood-Brain Barrier Penetration from Chemical Structure: Combining Passive Permeability with Active Efflux by P-Glycoprotein
[Image: see text] In order to reach their pharmacologic targets, successful central nervous system (CNS) drug candidates have to cross a complex protective barrier separating brain from the blood. Being able to predict a priori which molecules can successfully penetrate this barrier could be of sign...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2012
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582291/ https://ncbi.nlm.nih.gov/pubmed/23421687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3001922 |
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