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An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of genes responsible for iron uptake, release, use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2. However, the manner in which iron levels are sensed to affect IRP2 activity is p...

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Detalhes bibliográficos
Main Authors: Salahudeen, Ameen A., Thompson, Joel W., Ruiz, Julio C., Ma, He-Wen, Kinch, Lisa N., Li, Qiming, Grishin, Nick V., Bruick, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582197/
https://ncbi.nlm.nih.gov/pubmed/19762597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1176326
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