Epigenomic plasticity enables human pancreatic α to β cell reprogramming

Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α, β, and exocrin...

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Main Authors: Bramswig, Nuria C., Everett, Logan J., Schug, Jonathan, Dorrell, Craig, Liu, Chengyang, Luo, Yanping, Streeter, Philip R., Naji, Ali, Grompe, Markus, Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582140/
https://ncbi.nlm.nih.gov/pubmed/23434589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66514
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