PAR-1 contributes to the innate immune response during viral infection

Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1(...

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Hlavní autoři: Antoniak, Silvio, Owens, A. Phillip, Baunacke, Martin, Williams, Julie C., Lee, Rebecca D., Weithäuser, Alice, Sheridan, Patricia A., Malz, Ronny, Luyendyk, James P., Esserman, Denise A., Trejo, JoAnn, Kirchhofer, Daniel, Blaxall, Burns C., Pawlinski, Rafal, Beck, Melinda A., Rauch, Ursula, Mackman, Nigel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582138/
https://ncbi.nlm.nih.gov/pubmed/23391721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66125
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