PAR-1 contributes to the innate immune response during viral infection

Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1(...

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Główni autorzy: Antoniak, Silvio, Owens, A. Phillip, Baunacke, Martin, Williams, Julie C., Lee, Rebecca D., Weithäuser, Alice, Sheridan, Patricia A., Malz, Ronny, Luyendyk, James P., Esserman, Denise A., Trejo, JoAnn, Kirchhofer, Daniel, Blaxall, Burns C., Pawlinski, Rafal, Beck, Melinda A., Rauch, Ursula, Mackman, Nigel
Format: Artigo
Język:Inglês
Wydane: American Society for Clinical Investigation 2013
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582138/
https://ncbi.nlm.nih.gov/pubmed/23391721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66125
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