SHP-1 phosphatase activity counteracts increased T cell receptor affinity

Anti-self/tumor T cell function can be improved by increasing TCR-peptide MHC (pMHC) affinity within physiological limits, but paradoxically further increases (K(d) < 1 μM) lead to drastic functional declines. Using human CD8(+) T cells engineered with TCRs of incremental affinity for the tumor a...

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Main Authors: Hebeisen, Michael, Baitsch, Lukas, Presotto, Danilo, Baumgaertner, Petra, Romero, Pedro, Michielin, Olivier, Speiser, Daniel E., Rufer, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582132/
https://ncbi.nlm.nih.gov/pubmed/23391724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65325
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