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Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis

Aldoxime dehydratase (OxdA), which is a unique heme protein, catalyzes the dehydration of an aldoxime to a nitrile even in the presence of water in the reaction mixture. Unlike the utilization of H(2)O(2) or O(2) as a mediator of catalysis by other heme-containing enzymes (e.g., P450), OxdA is notab...

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Autors principals: Nomura, Junpei, Hashimoto, Hiroshi, Ohta, Takehiro, Hashimoto, Yoshiteru, Wada, Koichi, Naruta, Yoshinori, Oinuma, Ken-Ichi, Kobayashi, Michihiko
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581911/
https://ncbi.nlm.nih.gov/pubmed/23382199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200338110
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