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Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors
The G-protein–mediated Rho guanine nucleotide exchange factor (GEF)–Rho GTPase signaling axis has been implicated in human pathophysiology and is a potential therapeutic target. By virtual screening of chemicals that fit into a surface groove of the DH-PH domain of LARG, a G-protein–regulated Rho GE...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581902/ https://ncbi.nlm.nih.gov/pubmed/23382194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212324110 |
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