NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome

Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to molecular triggers such as pathogen-associated or damage-associated molecular patterns, the NLRP1 inflammasome promotes caspase-1–dependent proces...

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Main Authors: Levandowski, Cecilia B., Mailloux, Christina M., Ferrara, Tracey M., Gowan, Katherine, Ben, Songtao, Jin, Ying, McFann, Kimberly K., Holland, Paulene J., Fain, Pamela R., Dinarello, Charles A., Spritz, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581876/
https://ncbi.nlm.nih.gov/pubmed/23382179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222808110
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