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Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: A periodic paralysis mutation in Na(V)1.4 (L689I)
In skeletal muscle, slow inactivation (SI) of Na(V)1.4 voltage-gated sodium channels prevents spontaneous depolarization and fatigue. Inherited mutations in Na(V)1.4 that impair SI disrupt activity-induced regulation of channel availability and predispose patients to hyperkalemic periodic paralysis....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581693/ https://ncbi.nlm.nih.gov/pubmed/23401572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210910 |
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