Hypoxia Inducible Factor 3α Plays a Critical Role in Alveolarization and Distal Epithelial Cell Differentiation during Mouse Lung Development

Lung development occurs under relative hypoxia and the most important oxygen-sensitive response pathway is driven by Hypoxia Inducible Factors (HIF). HIFs are heterodimeric transcription factors of an oxygen-sensitive subunit, HIFα, and a constitutively expressed subunit, HIF1β. HIF1α and HIF2α, enc...

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Detalhes bibliográficos
Main Authors: Huang, Yadi, Kapere Ochieng, Joshua, Kempen, Marjon Buscop-van, Munck, Anne Boerema-de, Swagemakers, Sigrid, van IJcken, Wilfred, Grosveld, Frank, Tibboel, Dick, Rottier, Robbert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581546/
https://ncbi.nlm.nih.gov/pubmed/23451260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057695
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