Caspase-2 Is Upregulated after Sciatic Nerve Transection and Its Inhibition Protects Dorsal Root Ganglion Neurons from Apoptosis after Serum Withdrawal

Sciatic nerve (SN) transection-induced apoptosis of dorsal root ganglion neurons (DRGN) is one factor determining the efficacy of peripheral axonal regeneration and the return of sensation. Here, we tested the hypothesis that caspase-2 (CASP2) orchestrates apoptosis of axotomised DRGN both in vivo a...

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Bibliografiska uppgifter
Huvudupphovsmän: Vigneswara, Vasanthy, Berry, Martin, Logan, Ann, Ahmed, Zubair
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581492/
https://ncbi.nlm.nih.gov/pubmed/23451279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057861
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