Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3

Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1–3), all producing an identical polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid. To compare the properties of these isoenzymes, COS-1 cells, with minor endogenous hyaluronan synthesis, were tran...

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Main Authors: Rilla, Kirsi, Oikari, Sanna, Jokela, Tiina A., Hyttinen, Juha M. T., Kärnä, Riikka, Tammi, Raija H., Tammi, Markku I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581382/
https://ncbi.nlm.nih.gov/pubmed/23303191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443879
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