Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location

Phosphatidylinositol (PI) 4,5-bisphosphate (PIP(2)), generated by PI 4-phosphate 5-kinase (PIP5K), regulates many critical cellular events. PIP(2) is also known to mediate plasma membrane localization of the Toll/IL-1 receptor domain-containing adaptor protein (TIRAP), required for the MyD88-depende...

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Dettagli Bibliografici
Autori principali: Nguyen, Tu Thi Ngoc, Kim, Yong Min, Kim, T. Doohun, Le, Oanh Thi Tu, Kim, Jae Jin, Kang, Ho Chul, Hasegawa, Hiroshi, Kanaho, Yasunori, Jou, Ilo, Lee, Sang Yoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581370/
https://ncbi.nlm.nih.gov/pubmed/23297396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410126
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