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New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening

The recently discovered 150-residue human VHZ (VH1 related protein, Z member) is one of the smallest protein tyrosine phosphatases (PTPs) known, and contains only the minimal structural elements common to all PTPs. We report a substrate screening analysis and a crystal structure of the VHZ complex w...

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書誌詳細
主要な著者: Kuznetsov, Vyacheslav I., Hengge, Alvan C., Johnson, Sean J.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581349/
https://ncbi.nlm.nih.gov/pubmed/23145819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300908y
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